Ser245

Site Information
FPLRKTAsEPNLKLR SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 448488

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 ) , mutation of modification site ( 2 )
Disease tissue studied:	bone cancer ( 2 )
Relevant cell line - cell type - tissue:	beta-pancreas ( 1 ) , UMR106 (bone cell) ( 2 )

Upstream Regulation
Treatments:	high_glucose ( 1 ) , okadaic_acid ( 2 ) , PTH ( 2 )

References
1	Kang T, et al. (2018) Characterization of the Molecular Mechanisms Underlying Glucose Stimulated Insulin Secretion from Isolated Pancreatic β-cells Using Post-translational Modification Specific Proteomics (PTMomics). Mol Cell Proteomics 17, 95-110 29113996 Curated Info
2	Shimizu E, Nakatani T, He Z, Partridge NC (2014) Parathyroid Hormone Regulates Histone Deacetylase (HDAC) 4 through Protein Kinase A-mediated Phosphorylation and Dephosphorylation in Osteoblastic Cells. J Biol Chem 289, 21340-50 24904057 Curated Info