Ser471
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Home > Phosphorylation Site Page: > Ser471  -  p73 (human)

Site Information
GEMSSSHsAQSMVSG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 18944909

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , immunoassay ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 )
Disease tissue studied:
breast cancer ( 1 ) , breast ductal carcinoma ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , HCC1937 (breast cell) ( 1 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Putative in vivo kinases:
IKKB (human) ( 1 )
Kinases, in vitro:
IKKB (human) ( 1 )

Downstream Regulation
Effects of modification on p73:
intracellular localization ( 1 ) , molecular association, regulation ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , transcription, inhibited ( 1 )
Induce interaction with:
DNA ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
breast cancer ( 1 )

References 

1

Accardi R, et al. (2011) I{kappa}B Kinase {beta} Promotes Cell Survival by Antagonizing p53 Functions through {Delta}Np73{alpha} Phosphorylation and Stabilization. Mol Cell Biol 31, 2210-26
21482671   Curated Info