Tyr214

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Home > Phosphorylation Site Page: > Tyr214 - cGAS (human)

Site Information
GLLNTGSyyEHVKIs SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 1886659902

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 ) , mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 1 )

Upstream Regulation
Putative in vivo kinases:	Syk (human) ( 1 )

Downstream Regulation
Effects of modification on cGAS:	enzymatic activity, induced ( 1 ) , molecular association, regulation ( 1 )
Induce interaction with:	DNA ( 1 )

References
1	Yang YL, et al. (2022) Endocytosis triggers V-ATPase-SYK-mediated priming of cGAS activation and innate immune response. Proc Natl Acad Sci U S A 119, e2207280119 36252040 Curated Info

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