Lys267

Site Information
EVMTRLMkHLGLEIP SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 1885720100

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:	lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:	A549 (pulmonary) ( 1 ) , HEK293T (epithelial) ( 1 ) , NCI-H1299 (pulmonary) ( 1 )

Downstream Regulation
Effects of modification on SIRT6:	enzymatic activity, inhibited ( 1 ) , intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:	carcinogenesis, induced ( 1 ) , transcription, induced ( 1 )
Inhibit interaction with:	FOXA2 (human) ( 1 )

References
1	Zhao K, et al. (2023) MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC. Cell Rep 42, 112939 37566546 Curated Info