Ser489
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Home > Phosphorylation Site Page: > Ser489  -  AHR (human)

Site Information
ENNFFNEsMNECRNW   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1884386102

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lung cancer ( 1 ) , mesothelioma ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 ) , non-small cell squamous cell lung carcinoma ( 1 ) , small-cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PLK1 (human) ( 1 )
Kinases, in vitro:
PLK1 (human) ( 1 )
Treatments:
nocodazole ( 1 ) , onvansertib ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on AHR:
activity, inhibited ( 1 ) , protein conformation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell motility, induced ( 1 ) , signaling pathway regulation ( 1 ) , transcription, altered ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
non-small cell lung adenocarcinoma, surrounding tissue ( 1 )

References 

1

Li C, et al. (2023) Phosphorylation of AHR by PLK1 promotes metastasis of LUAD via DIO2-TH signaling. PLoS Genet 19, e1011017
37988371   Curated Info