Lys256
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Home > Ubiquitylation Site Page: > Lys256  -  GATA4 (human)

Site Information
GINRPLIkPQRRLsA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1883526402

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
H9c2 (myoblast) ( 1 ) , HEK293T (epithelial) ( 1 ) , myocyte-heart ( 1 )

Upstream Regulation
Regulatory protein:
DEC1 (human) ( 1 )

Downstream Regulation
Effects of modification on GATA4:
protein degradation ( 1 ) , ubiquitination ( 1 )

References 

1

Cheng L, et al. (2022) DEC1 represses cardiomyocyte hypertrophy by recruiting PRP19 as an E3 ligase to promote ubiquitination-proteasome-mediated degradation of GATA4. J Mol Cell Cardiol 169, 96-110
35659652   Curated Info

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