Ser218
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Home > Phosphorylation Site Page: > Ser218  -  RSK3 (human)

Site Information
DHDKRAysFCGtIEY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1883400

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 2 )
Disease tissue studied:
lung cancer ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , A549 (pulmonary) ( 1 ) , Jurkat (T lymphocyte) ( 1 )

Upstream Regulation
Kinases, in vitro:
RSK3 (human) ( 3 )

Downstream Regulation
Effects of modification on RSK3:
enzymatic activity, induced ( 3 ) , molecular association, regulation ( 2 )
Inhibit interaction with:
AKAP6 (mouse) ( 2 )

References 

1

Wissing J, et al. (2007) Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. Mol Cell Proteomics 6, 537-47
17192257   Curated Info

2

Michel JJ, et al. (2005) Spatial restriction of PDK1 activation cascades by anchoring to mAKAPalpha. Mol Cell 20, 661-72
16337591   Curated Info

3

Bjørbaek C, Zhao Y, Moller DE (1995) Divergent functional roles for p90rsk kinase domains. J Biol Chem 270, 18848-52
7642538   Curated Info

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