Ser184
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.5
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser184  -  CTNNB1 (human)

Site Information
QLskKEAsRHAIMRs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1881579404

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
liver cancer ( 1 ) , hepatocellular carcinoma ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , embryo ( 1 ) , Hep3B (hepatic) ( 1 ) , Huh7 (hepatic) ( 1 ) , liver ( 1 )

Upstream Regulation
Putative in vivo kinases:
PMVK (human) ( 1 )
Kinases, in vitro:
PMVK (human) ( 1 )
Treatments:
methyl-beta-cyclodextrin ( 1 ) , mevalonate 5-diphosphate ( 1 ) , mevalonate 5-phosphate ( 1 ) , PMVKi5 ( 1 )

Downstream Regulation
Effects of modification on CTNNB1:
intracellular localization ( 1 ) , molecular association, regulation ( 1 ) , phosphorylation ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , signaling pathway regulation ( 1 ) , transcription, induced ( 1 )
Inhibit interaction with:
BTRC (human) ( 1 ) , CK1A (human) ( 1 ) , GSK3B (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
hepatocellular carcinoma ( 1 )

References 

1

Chen Z, et al. (2023) Phosphomevalonate Kinase Controls β-Catenin Signaling via the Metabolite 5-Diphosphomevalonate. Adv Sci (Weinh) 10, e2204909
36808719   Curated Info