Lys295
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Home > Acetylation Site Page: > Lys295  -  SQSTM1 (human)

Site Information
sCCsDPskPGGNVEG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1881279900

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , modification-specific antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
liver cancer ( 1 ) , liver adenocarcinoma ( 1 ) , hepatocellular carcinoma ( 1 )
Relevant cell line - cell type - tissue:
Huh7 (hepatic) ( 1 ) , PLC/PRF/5 (hepatic) ( 1 ) , SK-HEP-1 (endothelial) ( 1 )

Upstream Regulation
Treatments:
nicotinamide ( 1 ) , trichostatin_A ( 1 )

Downstream Regulation
Effects of modification on SQSTM1:
protein degradation ( 1 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 1 )

References 

1

Feng L, et al. (2021) Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis. Cell Death Dis 12, 405
33854041   Curated Info

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