Tyr816
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Home > S-Nitrosylation Site Page: > Tyr816  -  TrkB (mouse)

Site Information
LAKASPVyLDILG__   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1881005700

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
'brain, frontal cortex' ( 1 ) , 'brain, hippocampus' ( 1 ) , brain ( 1 ) , Neuro-2a (neuron) ( 1 ) , neuron ( 1 )

Upstream Regulation
Treatments:
N-nitro-L-arginine ( 1 ) , NPA ( 1 ) , SNP ( 1 )

Downstream Regulation
Effects of modification on TrkB:
intracellular localization ( 1 ) , molecular association, regulation ( 1 ) , phosphorylation ( 1 ) , protein conformation ( 1 ) , protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
endocytosis, induced ( 1 ) , signaling pathway regulation ( 1 )
Induce interaction with:
AP2M1 (human) ( 1 )
Inhibit interaction with:
PLCG1 (human) ( 1 )

References 

1

Biojone C, et al. (2023) nNOS-induced tyrosine nitration of TRKB impairs BDNF signaling and restrains neuronal plasticity. Prog Neurobiol 222, 102413
36682419   Curated Info