Lys103

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Home > Ubiquitylation Site Page: > Lys103 - SMPD3 (human)

Site Information
IYSRLEDkGLAGGAA SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 1880099300

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:	colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , NAFLD ( 1 )
Relevant cell line - cell type - tissue:	SW480 (intestinal) ( 1 )

Upstream Regulation
Treatments:	cigarette_smoke ( 1 )

Downstream Regulation
Effects of modification on SMPD3:	protein degradation ( 1 )

References
1	Chen B, et al. (2022) Gut bacteria alleviate smoking-related NASH by degrading gut nicotine. Nature 610, 562-568 36261549 Curated Info

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