Lys383
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Home > Acetylation Site Page: > Lys383  -  STAT6 (mouse)

Site Information
TESVTEEkCAVLFST   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1880010904

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 1 , 2 ) , immunoprecipitation ( 1 , 2 ) , mass spectrometry ( 2 ) , modification-specific antibody ( 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
lymphocyte ( 1 ) , macrophage-bone marrow ( 2 )

Upstream Regulation
Treatments:
nicotinamide ( 2 ) , trichostatin_A ( 2 )

Downstream Regulation
Effects of modification on STAT6:
acetylation ( 1 ) , activity, inhibited ( 1 )
Effects of modification on biological processes:
transcription, altered ( 1 ) , transcription, inhibited ( 2 )
Inhibit interaction with:
DNA ( 2 )

References 

1

Yue L, et al. (2023) TRIM24-Mediated Acetylation of STAT6 Suppresses Th2-Induced Allergic Rhinitis. Allergy Asthma Immunol Res 15, 603-613
37827979   Curated Info

2

Yu T, et al. (2019) Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24. Nat Commun 10, 4353
31554795   Curated Info