Lys151
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Home > Ubiquitylation Site Page: > Lys151  -  NKX2-1 (human)

Site Information
GSLGDVSkNMAPLPS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1877644900

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:
A549 (pulmonary) ( 1 ) , BEAS-2B (epithelial) ( 1 ) , HBE (epithelial) ( 1 ) , HEK293T (epithelial) ( 1 ) , MLE12 (epithelial) ( 1 )

Upstream Regulation
Treatments:
phorbol_ester ( 1 )

Downstream Regulation
Effects of modification on NKX2-1:
protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
cell growth, inhibited ( 1 ) , cell motility, inhibited ( 1 )

References 

1

Liu J, et al. (2019) The E3 ubiquitin ligase HECW1 targets thyroid transcription factor 1 (TTF1/NKX2.1) for its degradation in the ubiquitin-proteasome system. Cell Signal 58, 91-98
30849519   Curated Info