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Site Information |
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QYLGSIAsPSVHPAT SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 454400 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Putative in vivo kinases: | |
Kinases, in vitro: | |
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Downstream Regulation | |
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Effects of modification on AML1 iso8: | |
Effects of modification on biological processes: |
References | |
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Yoshimi M, et al. (2012) Multiple phosphorylation sites are important for RUNX1 activity in early hematopoiesis and T-cell differentiation. Eur J Immunol 42, 1044-50
22531928 Curated Info |
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Tachibana M, et al. (2008) Phosphorylation of Runx1 at Ser249, Ser266, and Ser276 is dispensable for bone marrow hematopoiesis and thymocyte differentiation. Biochem Biophys Res Commun 368, 536-42
18261462 Curated Info |
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Biggs JR, et al. (2006) AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex. Mol Cell Biol 26, 7420-9
17015473 Curated Info |
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Biggs JR, et al. (2005) Phosphorylation of AML1/RUNX1 regulates its degradation and nuclear matrix association. Mol Cancer Res 3, 391-401
16046550 Curated Info |
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Zhang Y, Biggs JR, Kraft AS (2004) Phorbol ester treatment of K562 cells regulates the transcriptional activity of AML1c through phosphorylation. J Biol Chem 279, 53116-25
15475366 Curated Info |