Tyr24
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Home > Phosphorylation Site Page: > Tyr24  -  PEAK3 (human)

Site Information
TWSTQPTySNLGQIR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1876371802

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:
MCF10A1 (epithelial) ( 1 ) , MDA-MB-231 (breast cell) ( 1 )

Upstream Regulation
Regulatory protein:
PTP-PEST (human) ( 1 )
Treatments:
dasatinib ( 1 ) , eCF506 ( 1 ) , EGF ( 1 )

Downstream Regulation
Effects of modification on PEAK3:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 ) , cell motility, induced ( 1 ) , signaling pathway regulation ( 1 )
Induce interaction with:
CDK6 (mouse) ( 1 ) , GRB2 (human) ( 1 )

References 

1

Hou J, et al. (2022) Distinct PEAK3 interactors and outputs expand the signaling potential of the PEAK pseudokinase family. Sci Signal 15, eabj3554
35192416   Curated Info

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