Ser228
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Home > Phosphorylation Site Page: > Ser228  -  SDS3 (mouse)

Site Information
RTLNKLKsPKRPAsP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454398

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 3 , 4 , 5 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
brain cancer ( 3 , 4 , 5 ) , neuroendocrine cancer ( 3 , 4 , 5 )
Relevant cell line - cell type - tissue:
'brain, embryonic' ( 2 ) , 'neuron, cerebellar granule'-brain ( 2 ) , brain ( 3 , 4 , 5 ) , HEK293T (epithelial) ( 2 )

Upstream Regulation
Putative in vivo kinases:
CDK5 (human) ( 2 )
Kinases, in vitro:
CDK5 (human) ( 6 )
Treatments:
seliciclib ( 2 )

Downstream Regulation
Effects of modification on SDS3:
acetylation ( 2 ) , activity, induced ( 2 )
Effects of modification on biological processes:
apoptosis, induced ( 2 ) , cell growth, altered ( 6 ) , transcription, altered ( 2 )

References 

1

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

2

Fu AK, et al. (2013) Cdk5 phosphorylates a component of the HDAC complex and regulates histone acetylation during neuronal cell death. Neurosignals 21, 55-60
22398430   Curated Info

3

Guo A (2011) CST Curation Set: 12736; Year: 2011; Biosample/Treatment: tissue, brain/untreated; Disease: brain cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: PXpSP, pSPX(K/R) Antibodies Used to Purify Peptides prior to LCMS: Phospho-MAPK/CDK Substrates (PXSP or SPXR/K) (34B2) Rabbit mAb Cat#: 2325, PTMScan(R) Phospho-MAPK/CDK Substrate Motif (PXS*P, S*PXK/R) Immunoaffinity Beads Cat#: 1982
Curated Info

4

Guo A (2011) CST Curation Set: 12738; Year: 2011; Biosample/Treatment: tissue, brain/untreated; Disease: brain cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: PXpSP, pSPX(K/R) Antibodies Used to Purify Peptides prior to LCMS: Phospho-MAPK/CDK Substrates (PXSP or SPXR/K) (34B2) Rabbit mAb Cat#: 2325, PTMScan(R) Phospho-MAPK/CDK Substrate Motif (PXS*P, S*PXK/R) Immunoaffinity Beads Cat#: 1982
Curated Info

5

Guo A (2011) CST Curation Set: 12739; Year: 2011; Biosample/Treatment: tissue, brain/untreated; Disease: brain cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: PXpSP, pSPX(K/R) Antibodies Used to Purify Peptides prior to LCMS: Phospho-MAPK/CDK Substrates (PXSP or SPXR/K) (34B2) Rabbit mAb Cat#: 2325, PTMScan(R) Phospho-MAPK/CDK Substrate Motif (PXS*P, S*PXK/R) Immunoaffinity Beads Cat#: 1982
Curated Info

6

Li Z, et al. (2004) Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription. J Biol Chem 279, 54438-44
15489224   Curated Info

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