Ser285
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Home > Phosphorylation Site Page: > Ser285  -  PRPS1 (human)

Site Information
EDkMKHCsKIQVIDI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1874748500

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , cancer, squamous cell carcinoma ( 1 )
Relevant cell line - cell type - tissue:
HCT116 (intestinal) ( 1 ) , HSC-3 (squamous) ( 1 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Regulatory protein:
MST1 (human) ( 1 ) , MST2 (human) ( 1 )
Putative in vivo kinases:
LATS1 (human) ( 1 ) , LATS2 (human) ( 1 )
Kinases, in vitro:
LATS1 (human) ( 1 ) , LATS2 (human) ( 1 )
Treatments:
(-)-Blebbistatin ( 1 ) , stiff ECM substrate ( 1 ) , U73122 ( 1 ) , Y27632 ( 1 )

Downstream Regulation
Effects of modification on PRPS1:
molecular association, regulation ( 1 ) , protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 1 ) , cell growth, inhibited ( 1 )
Induce interaction with:
TRAF2 (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
colorectal cancer ( 1 )

References 

1

Li J, et al. (2021) Mechanosensitive turnover of phosphoribosyl pyrophosphate synthetases regulates nucleotide metabolism. Cell Death Differ
34465890   Curated Info

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