Tyr766
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Home > Phosphorylation Site Page: > Tyr766  -  FGFR1 (mouse)

Site Information
ALTSNQEyLDLSIPL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447922

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 )
Relevant cell line - cell type - tissue:
embryo [FGFR1 (mouse), transgenic] ( 2 ) , IBE (endothelial) ( 1 )

Downstream Regulation
Effects of modification on FGFR1:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 ) , cell growth, altered ( 2 ) , transcription, altered ( 2 )
Induce interaction with:
SHB (mouse) ( 1 )

References 

1

Cross MJ, et al. (2002) The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells. Mol Biol Cell 13, 2881-93
12181353   Curated Info

2

Partanen J, Schwartz L, Rossant J (1998) Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Genes Dev 12, 2332-44
9694798   Curated Info