Ser677

Site Information
RVGKQLAsQKILQLL SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 1874101914

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:	breast cancer ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:	BT-549 (breast cell) ( 1 ) , HEK293T (epithelial) ( 1 ) , LM (fibroblast) ( 1 )

Downstream Regulation
Effects of modification on DGCR8:	intracellular localization ( 1 ) , molecular association, regulation ( 1 ) , protein stabilization ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:	DNA repair, induced ( 1 )
Induce interaction with:	USP51 (human) ( 1 )

References
1	Hang Q, et al. (2021) Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance. Nat Commun 12, 4033 34188037 Curated Info