Ser49
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Home > Phosphorylation Site Page: > Ser49  -  SMN (human)

Site Information
AyDkAVAsFkHALkN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1873529903

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
chronic myelogenous leukemia ( 1 )
Relevant cell line - cell type - tissue:
HAP1 ( 1 ) , IMR-90 (fibroblast) ( 1 )

Upstream Regulation
Putative in vivo kinases:
p70S6K (human) ( 1 )
Kinases, in vitro:
p70S6K (human) ( 1 )
Treatments:
amino_acid_starvation ( 1 ) , serum_starvation ( 1 ) , Torin1 ( 1 )

Downstream Regulation
Effects of modification on SMN:
molecular association, regulation ( 1 ) , protein conformation ( 1 )
Effects of modification on biological processes:
cell growth, induced ( 1 )
Induce interaction with:
SMN (human) ( 1 )

References 

1

Schilling M, et al. (2021) TOR signaling regulates liquid phase separation of the SMN complex governing snRNP biogenesis. Cell Rep 35, 109277
34161763   Curated Info

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