Lys248
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.5
Powered by Cell Signaling Technology
Home > Methylation Site Page: > Lys248  -  PCNA (human)

Site Information
IADMGHLkYyLAPkI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1872852100

In vivo Characterization
Methods used to characterize site in vivo:
amino acid analysis ( 1 ) , immunoassay ( 1 ) , immunoprecipitation ( 1 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bladder cancer ( 1 ) , colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , liver cancer ( 1 ) , hepatocellular carcinoma ( 1 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 ) , small-cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
siRNA ( 1 )

Downstream Regulation
Effects of modification on PCNA:
molecular association, regulation ( 1 ) , protein stabilization ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell cycle regulation ( 1 ) , cell growth, induced ( 1 ) , DNA repair, induced ( 1 )
Induce interaction with:
FEN1 (human) ( 1 )

References 

1

Takawa M, et al. (2012) Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression. Cancer Res 72, 3217-27
22556262   Curated Info