Tyr433
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Home > Phosphorylation Site Page: > Tyr433  -  TrkB (mouse)

Site Information
NREHLSVyAVVVIAS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1872544500

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
'brain, hippocampus, dentate gyrus' ( 1 ) , 'neuron, cortical' ( 1 ) , HEK293T (epithelial) ( 1 ) , MG87 (fibroblast) ( 1 ) , Neuro-2a (neuron) ( 1 ) , neuron-'brain, hippocampus' ( 1 )

Downstream Regulation
Effects of modification on TrkB:
intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
neural plasticity ( 1 ) , signaling pathway regulation ( 1 )
Induce interaction with:
Fyn (human) ( 1 ) , Other ( 1 ) , TrkB (human) ( 1 )

References 

1

Casarotto PC, et al. (2021) Antidepressant drugs act by directly binding to TRKB neurotrophin receptors. Cell 184, 1299-1313.e19
33606976   Curated Info