Lys268

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Home > Acetylation Site Page: > Lys268 - Tip60 (human)

Site Information
YLCEFCLkYGRSLkC SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 1872267900

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:	leukemia ( 1 ) , T cell leukemia ( 1 )
Relevant cell line - cell type - tissue:	COS (fibroblast) ( 1 ) , Jurkat (T lymphocyte) ( 1 )

Upstream Regulation
Treatments:	siRNA ( 1 )

Downstream Regulation
Effects of modification on Tip60:	protein degradation ( 1 )
Effects of modification on biological processes:	apoptosis, inhibited ( 1 )

References
1	Col E, et al. (2005) HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses. EMBO J 24, 2634-45 16001085 Curated Info

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