Ser332
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Home > Phosphorylation Site Page: > Ser332  -  OTUD5 (mouse)

Site Information
HRNIHYNsVVNPNKA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1870773110

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 )
Disease tissue studied:
breast cancer ( 1 ) , colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , HEK293T (epithelial) ( 1 ) , HT-29 (intestinal) ( 1 ) , MCF-7 (breast cell) ( 1 )

Upstream Regulation
Regulatory protein:
TSC1 (human) ( 1 )
Putative in vivo kinases:
mTOR (mouse) ( 1 )
Kinases, in vitro:
mTOR (mouse) ( 1 )
Treatments:
amino_acids ( 1 ) , bortezomib ( 1 ) , glucose ( 1 ) , rapamycin ( 1 ) , starvation ( 1 )

Downstream Regulation
Effects of modification on OTUD5:
enzymatic activity, induced ( 1 ) , molecular association, regulation ( 1 ) , phosphorylation ( 1 ) , protein degradation ( 1 ) , protein stabilization ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
autophagy, inhibited ( 1 ) , cell cycle regulation ( 1 ) , cell growth, induced ( 1 ) , signaling pathway regulation ( 1 ) , transcription, altered ( 1 )
Inhibit interaction with:
BTRC (human) ( 1 )

References 

1

Cho JH, et al. (2020) Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways. Cell Death Differ
33110214   Curated Info

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