Ser264
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Home > Phosphorylation Site Page: > Ser264  -  PCAF (human)

Site Information
YWHLEAPsQRRLRsP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1870426001

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
ATR (human) ( 1 )
Treatments:
hydroxyurea ( 1 ) , VE-821 ( 1 )

Downstream Regulation
Effects of modification on PCAF:
acetylation ( 1 ) , molecular association, regulation ( 1 )
Inhibit interaction with:
DNA ( 1 )

References 

1

Kim JJ, et al. (2020) PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells. Mol Cell
32966758   Curated Info