Ser2114
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Home > Phosphorylation Site Page: > Ser2114  -  Huntingtin (human)

Site Information
QCWTRsDsALLEGAE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1870026105

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
LCL (lymphoblastoid) ( 1 ) , SF9 ( 1 )

Downstream Regulation
Effects of modification on Huntingtin:
activity, induced ( 1 ) , molecular association, regulation ( 1 ) , protein conformation ( 1 )
Inhibit interaction with:
PRRC2C (mouse) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
Huntington's disease ( 1 )

References 

1

Jung T, et al. (2020) The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain. Structure 28, 1035-1050.e8
32668197   Curated Info

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