Ser48
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Home > Phosphorylation Site Page: > Ser48  -  SERT (human)

Site Information
GQISNGysAVPSPGA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1869992415

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'brain, striatum' ( 1 ) , 293 (epithelial) ( 1 ) , neuron:synaptosome ( 1 )

Upstream Regulation
Putative in vivo kinases:
GSK3B (human) ( 1 )
Treatments:
CHIR99021 ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on SERT:
receptor internalization, inhibited ( 1 )

References 

1

Ragu Varman D, Jayanthi LD, Ramamoorthy S (2020) Glycogen synthase kinase-3ß supports serotonin transporter function and trafficking in a phosphorylation-dependent manner. J Neurochem
32797733   Curated Info

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