Ser384
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Home > Phosphorylation Site Page: > Ser384  -  CASP2 (mouse)

Site Information
MRNTKRGsWYIEALT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1869992407

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 )
Disease tissue studied:
bone cancer ( 1 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:
A549 (pulmonary) ( 1 ) , E.coli (bacterial) ( 1 ) , U2OS (bone cell) ( 1 )

Upstream Regulation
Putative in vivo kinases:
AurB (human) ( 1 )
Kinases, in vitro:
AurB (mouse) ( 1 )
Treatments:
ZM447439 ( 1 )

Downstream Regulation
Effects of modification on CASP2:
enzymatic activity, inhibited ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , cell cycle regulation ( 1 )

References 

1

Lim Y, et al. (2020) Phosphorylation by Aurora B kinase regulates caspase-2 activity and function. Cell Death Differ
32811973   Curated Info