Thr55
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Home > Phosphorylation Site Page: > Thr55  -  p21Cip1 (human)

Site Information
RWNFDFVtEtPLEGD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1869957900

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 1 ) , microscopy-colocalization with upstream kinase ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
obesity, hyperphagic ( 1 )
Relevant cell line - cell type - tissue:
'blood, serum' ( 1 ) , 293 (epithelial) ( 1 ) , 3T3-L1 (fibroblast) ( 1 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Putative in vivo kinases:
MELK (mouse) ( 1 )
Kinases, in vitro:
MELK (mouse) ( 1 )

Downstream Regulation
Effects of modification on p21Cip1:
activity, induced ( 1 ) , intracellular localization ( 1 ) , molecular association, regulation ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 1 ) , cell cycle regulation ( 1 ) , cell differentiation, inhibited ( 1 ) , cell growth, inhibited ( 1 ) , signaling pathway regulation ( 1 )
Induce interaction with:
CDK2 (human) ( 1 ) , CDK4 (human) ( 1 ) , PPAR-gamma (mouse) ( 1 )
Inhibit interaction with:
MDM2 (human) ( 1 )

References 

1

Seong HA, Ha H (2019) Thr55 phosphorylation of p21 by MPK38/MELK ameliorates defects in glucose, lipid, and energy metabolism in diet-induced obese mice. Cell Death Dis 10, 380
31097688   Curated Info