Tyr135
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Home > Phosphorylation Site Page: > Tyr135  -  CXCR4 (human)

Site Information
AFISLDRyLAIVHAT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1869808401

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
CXCL12 (human) ( 1 ) , VEGFR2 (human) ( 1 )
Treatments:
peptide_antagonist ( 1 ) , vandetanib ( 1 ) , VEGFR2 II ( 1 )

Downstream Regulation
Effects of modification on CXCR4:
activity, induced ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell motility, induced ( 1 )

References 

1

Jung O, Beauvais DM, Adams KM, Rapraeger AC (2019) VLA-4 phosphorylation during tumor and immune cell migration relies on its coupling to VEGFR2 and CXCR4 by syndecan-1. J Cell Sci 132
31562188   Curated Info