Ser435
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Home > Phosphorylation Site Page: > Ser435  -  cGAS (human)

Site Information
KHLDKFSsYHVKTAF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1869388601

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
glioblastoma multiforme ( 1 ) , glioma ( 1 ) , leukemia ( 1 ) , acute myelogenous leukemia ( 1 )
Relevant cell line - cell type - tissue:
T98G (glial) ( 1 ) , THP1 (myeloid) ( 1 )

Upstream Regulation
Treatments:
dsDNA ( 1 ) , NU7441 ( 1 )

Downstream Regulation
Effects of modification on biological processes:
carcinogenesis, altered ( 1 ) , transcription, induced ( 1 )

References 

1

Taffoni C, et al. (2022) DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma. EMBO J, e111961
36574362   Curated Info

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