Ser420
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Home > Phosphorylation Site Page: > Ser420  -  cGAS (mouse)

Site Information
QELDAFCsYHVKTAI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1869388601

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
fibrosarcoma of soft tissue ( 1 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 1 ) , HEK293T (epithelial) ( 1 ) , L929 (fibroblast) ( 1 )

Upstream Regulation
Putative upstream phosphatases:
PPP6C (mouse) ( 1 )
Treatments:
virus infection ( 1 )

Downstream Regulation
Effects of modification on cGAS:
enzymatic activity, induced ( 1 ) , molecular association, regulation ( 1 ) , protein conformation ( 1 )
Effects of modification on biological processes:
transcription, induced ( 1 )
Induce interaction with:
DNA ( 1 )

References 

1

Li M, Shu HB (2020) Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response. Protein Cell
32474700   Curated Info

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