Thr436
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Home > O-GlcNAc Site Page: > Thr436  -  LATS2 (human)

Site Information
PNTVTAVtAAHILHP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1869341904

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
siRNA ( 1 ) , thiamet-G ( 1 )

Downstream Regulation
Effects of modification on LATS2:
enzymatic activity, inhibited ( 1 ) , molecular association, regulation ( 1 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 ) , signaling pathway regulation ( 1 )
Inhibit interaction with:
MOB1B (human) ( 1 )

References 

1

Kim E, et al. (2020) -GlcNAcylation on LATS2 disrupts the Hippo pathway by inhibiting its activity. Proc Natl Acad Sci U S A 117, 14259-14269
32513743   Curated Info