Ser480
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Home > Phosphorylation Site Page: > Ser480  -  IQGAP1 (human)

Site Information
NTVWKQLsSSVTGLT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1869135500

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 ) , non-small cell squamous cell lung carcinoma ( 1 )
Relevant cell line - cell type - tissue:
HCC827 (pulmonary) ( 1 ) , HEK293T (epithelial) ( 1 ) , lung ( 1 )

Upstream Regulation
Putative in vivo kinases:
KHS2 (human) ( 1 )
Kinases, in vitro:
KHS2 (human) ( 1 )

Downstream Regulation
Effects of modification on IQGAP1:
activity, induced ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell motility, induced ( 1 ) , signaling pathway regulation ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
non-small cell squamous cell lung carcinoma ( 1 )

References 

1

Chuang HC, et al. (2019) MAP4K3/GLK promotes lung cancer metastasis by phosphorylating and activating IQGAP1. Cancer Res 79
31431460   Curated Info

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