Thr10
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Home > Phosphorylation Site Page: > Thr10  -  G6PD-2 (mouse)

Site Information
EQVTLSRtQVCGILR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1869062303

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
brain cancer ( 1 ) , glioblastoma ( 1 ) , glioma ( 1 ) , leukemia ( 1 ) , acute myelogenous leukemia ( 1 ) , melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:
GL261 (glial) ( 1 ) , glial-brain ( 1 ) , M2 (melanocyte) ( 1 ) , THP1 (myeloid) ( 1 ) , U-251 MG (glial) ( 1 ) , U87MG (glial) ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKCD (mouse) ( 1 )
Kinases, in vitro:
PKCD (mouse) ( 1 )
Treatments:
CoCL2 ( 1 ) , culturing_of_cells ( 1 ) , EGF ( 1 ) , IL-1b ( 1 ) , M-CSF ( 1 ) , rottlerin ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on G6PD-2:
enzymatic activity, induced ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
glioblastoma multiforme ( 1 )

References 

1

Lu J, et al. (2020) Tumor-associated macrophage interleukin-β promotes glycerol-3-phosphate dehydrogenase activation, glycolysis and tumorigenesis in glioma cells. Cancer Sci 111, 1979-1990
32259365   Curated Info