Ser264

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Home > Phosphorylation Site Page: > Ser264 - SMAD3 (human)

Site Information
VDGFTDPsNSERFCL SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 1868957100

In vivo Characterization
Methods used to characterize site in vivo:	mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:	MC3T3-E1 (preosteoblast) ( 1 )

Downstream Regulation
Effects of modification on SMAD3:	activity, inhibited ( 1 ) , phosphorylation ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:	cell differentiation, inhibited ( 1 ) , cell growth, induced ( 1 ) , signaling pathway regulation ( 1 ) , transcription, inhibited ( 1 )

References
1	Kang H, et al. (2020) Somatic SMAD3-activating mutations cause melorheostosis by up-regulating the TGF-β/SMAD pathway. J Exp Med 217 32232430 Curated Info

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