Ser546
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Home > Phosphorylation Site Page: > Ser546  -  MAD1L1 (human)

Site Information
RTKVLHMsLNPTsVA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1868914507

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
ULK1 (human) ( 1 )
Kinases, in vitro:
ULK1 (human) ( 1 )
Treatments:
siRNA ( 1 )

Downstream Regulation
Effects of modification on MAD1L1:
intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell cycle regulation ( 1 ) , cell growth, induced ( 1 ) , chromatin organization, altered ( 1 )
Induce interaction with:
ROD1 (human) ( 1 ) , ZW10 (human) ( 1 ) , ZWILCH (human) ( 1 )

References 

1

Yuan F, et al. (2019) ULK1 phosphorylates Mad1 to regulate spindle assembly checkpoint. Nucleic Acids Res
31291454   Curated Info