Tyr268

Site Information
WPTQVEFyASGVSWS SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 1868624701

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:	lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:	A549 (pulmonary) ( 1 ) , HEK293T (epithelial) ( 1 ) , macrophage ( 1 )

Downstream Regulation
Effects of modification on PKHF1:	molecular association, regulation ( 1 )
Effects of modification on biological processes:	endocytosis, induced ( 1 ) , signaling pathway regulation ( 1 )
Induce interaction with:	caveolin-1 (mouse) ( 1 )

References
1	Li T, et al. (2019) An endosomal LAPF is required for macrophage endocytosis and elimination of bacteria. Proc Natl Acad Sci U S A 116, 12958-12963 31189603 Curated Info