Ser357
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Home > Phosphorylation Site Page: > Ser357  -  RIPK1 (human)

Site Information
GMGPVEEsWFAPSLE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1868502603

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Putative in vivo kinases:
ULK1 (human) ( 1 )
Kinases, in vitro:
ULK1 (human) ( 1 )
Treatments:
MRT68921 ( 1 ) , siRNA ( 1 ) , TNF ( 1 ) , Z-VAD-FMK ( 1 )

Downstream Regulation
Effects of modification on RIPK1:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 )
Inhibit interaction with:
RIPK3 (human) ( 1 )

References 

1

Wu W, et al. (2020) The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death. Cell Rep 31, 107547
32320653   Curated Info

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