Ser1217
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Home > Phosphorylation Site Page: > Ser1217  -  TSC2 (human)

Site Information
MSLENPLsPFSSDIN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1868502602

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
glioblastoma multiforme ( 1 ) , glioma ( 1 ) , breast cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
CDK4 (human) ( 1 ) , CDK6 (human) ( 1 )

Downstream Regulation
Effects of modification on TSC2:
activity, inhibited ( 1 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 ) , cell growth, induced ( 1 ) , translation, induced ( 1 )

References 

1

Romero-Pozuelo J, et al. (2020) Cdk4 and Cdk6 Couple the Cell-Cycle Machinery to Cell Growth via mTORC1. Cell Rep 31, 107504
32294430   Curated Info