Ser39
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Home > Phosphorylation Site Page: > Ser39  -  BAP37 (human)

Site Information
VAyGVREsVFTVEGG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1868188300

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AurA (human) ( 1 ) , PKCA (human) ( 2 )
Kinases, in vitro:
PKCA (human) ( 2 )
Phosphatases, in vitro:
PPP1CA (human) ( 2 )
Treatments:
17-beta-estradiol ( 2 ) , MLN8237 ( 1 ) , peptide inhibitor ( 2 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on BAP37:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
autophagy, induced ( 1 )
Induce interaction with:
LC3A (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
breast cancer ( 2 )

References 

1

Bertolin G, et al. (2021) Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2. Life Sci Alliance 4
33820826   Curated Info

2

Yoshimaru T, et al. (2017) A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells. Nat Commun 8, 15427
28555617   Curated Info