Ser280
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Home > Phosphorylation Site Page: > Ser280  -  PPAR-alpha (human)

Site Information
FHCCQCTsVETVTEL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1867858200

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
H9c2 (myoblast) ( 1 ) , myocyte-heart ( 1 )

Upstream Regulation
Putative in vivo kinases:
GSK3A (rat) ( 1 )
Kinases, in vitro:
GSK3A (human) ( 1 )
Treatments:
fenofibrate ( 1 ) , linoleic_acid ( 1 ) , oleic_acid ( 1 ) , palmitate ( 1 ) , pirinixic acid ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on PPAR-alpha:
activity, induced ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
transcription, induced ( 1 )
Induce interaction with:
DNA ( 1 ) , RXRA (rat) ( 1 )

References 

1

Nakamura M, et al. (2019) Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy. Cell Metab
30745182   Curated Info

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