Ser249
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Home > Phosphorylation Site Page: > Ser249  -  Snail1 (human)

Site Information
ARTFsRMsLLHKHQE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1867725600

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
PAR3 (human) ( 1 )
Putative in vivo kinases:
PKCZ (human) ( 1 )
Kinases, in vitro:
PKCZ (human) ( 1 )
Treatments:
PZ09 ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on Snail1:
molecular association, regulation ( 1 ) , protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 1 ) , signaling pathway regulation ( 1 )
Induce interaction with:
BTRC (human) ( 1 ) , PAR3 (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
breast cancer ( 1 )

References 

1

Jung HY, et al. (2019) Apical-basal polarity inhibits epithelial-mesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation. Nat Cell Biol 21, 359-371
30804505   Curated Info