Ser59
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Home > Phosphorylation Site Page: > Ser59  -  BIM (human)

Site Information
GDSCPHGsPQGPLAP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454235

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
PD0325901 ( 1 ) , U0124 ( 1 )

Downstream Regulation
Effects of modification on BIM:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 )
Induce interaction with:
LC8 (human) ( 1 ) , beclin 1 (human) ( 1 )

References 

1

Buchheit CL, et al. (2015) Anoikis evasion in inflammatory breast cancer cells is mediated by Bim-EL sequestration. Cell Death Differ 22, 1275-86
25526094   Curated Info

2

Gilley R, et al. (2012) CDK1, not ERK1/2 or ERK5, is required for mitotic phosphorylation of BIM(EL). Cell Signal 24, 170-80
21924351   Curated Info