Tyr161

Site Information
LGADGGLyQIPLPSS SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 454233

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:	COS (fibroblast) ( 1 ) , HEK293T (epithelial) ( 1 ) , K562 (erythroid) ( 2 ) , neuron-'brain, hippocampus' ( 1 )

Upstream Regulation
Kinases, in vitro:	Src (human) ( 1 )

Downstream Regulation
Induce interaction with:	PSD-95 (human) ( 1 )

References
1	Cho IH, et al. (2013) SPIN90 phosphorylation modulates spine structure and synaptic function. PLoS One 8, e54276 23342115 Curated Info
2	Moritz A (2007) CST Curation Set: 2507; Year: 2007; Biosample/Treatment: cell line, K562/-; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info

References

Cho IH, et al. (2013) SPIN90 phosphorylation modulates spine structure and synaptic function. PLoS One 8, e54276
23342115 Curated Info

Moritz A (2007) CST Curation Set: 2507; Year: 2007; Biosample/Treatment: cell line, K562/-; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info