Thr48
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Home > Phosphorylation Site Page: > Thr48  -  Survivin (human)

Site Information
AGFIHCPtENEPDLA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 18451300

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
CK2A1 (human) ( 1 )
Treatments:
TBB ( 1 )

Downstream Regulation
Effects of modification on Survivin:
intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
apoptosis, altered ( 1 ) , cell cycle regulation ( 1 )
Inhibit interaction with:
Borealin (human) ( 1 )

References 

1

Barrett RM, Colnaghi R, Wheatley SP (2011) Threonine 48 in the BIR domain of survivin is critical to its mitotic and anti-apoptotic activities and can be phosphorylated by CK2 in vitro. Cell Cycle 10, 538-48
21252625   Curated Info