Ser505
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Home > Phosphorylation Site Page: > Ser505  -  SRC-3 (human)

Site Information
SPVAGVHsPMAsSGN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454109

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 6 ) , mutation of modification site ( 1 , 3 , 4 , 5 , 6 ) , phospho-antibody ( 2 , 3 , 4 , 6 ) , western blotting ( 2 , 3 , 4 , 6 )
Disease tissue studied:
breast cancer ( 1 , 2 , 3 , 4 , 5 ) , breast ductal carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
Akt1 (human) ( 4 ) , ER-alpha (human) ( 6 ) , HER2 (human) ( 2 )
Putative in vivo kinases:
GSK3A (human) ( 4 )
Kinases, in vitro:
JNK1 (human) ( 6 ) , NLK (human) ( 1 ) , P38A (human) ( 6 )
Putative upstream phosphatases:
PDXP (human) ( 3 ) , PPP1CA (human) ( 3 ) , PPP2CA (human) ( 3 )
Treatments:
EGF ( 4 ) , estradiol ( 3 , 4 , 6 ) , insulin ( 4 ) , lithium ( 4 ) , LY294002 ( 4 ) , PD98059 ( 4 ) , siRNA ( 6 )

Downstream Regulation
Effects of modification on SRC-3:
activity, induced ( 4 ) , molecular association, regulation ( 4 , 6 ) , protein degradation ( 4 ) , ubiquitination ( 4 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 ) , signaling pathway regulation ( 4 ) , transcription, induced ( 1 , 4 , 5 )
Induce interaction with:
ER-alpha (human) ( 4 )
Inhibit interaction with:
ER-alpha (human) ( 6 )

References 

1

Wang X, et al. (2021) Therapeutic targeting of nemo-like kinase in primary and acquired endocrine-resistant breast cancer. Clin Cancer Res
33542078   Curated Info

2

Nikolai BC, et al. (2016) HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes. Cancer Res 76, 1463-75
26833126   Curated Info

3

Li C, et al. (2008) Essential phosphatases and a phospho-degron are critical for regulation of SRC-3/AIB1 coactivator function and turnover. Mol Cell 31, 835-49
18922467   Curated Info

4

Wu RC, Feng Q, Lonard DM, O'Malley BW (2007) SRC-3 coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock. Cell 129, 1125-40
17574025   Curated Info

5

Wu H, et al. (2006) Coordinated regulation of AIB1 transcriptional activity by sumoylation and phosphorylation. J Biol Chem 281, 21848-56
16760465   Curated Info

6

Wu RC, et al. (2004) Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways. Mol Cell 15, 937-49
15383283   Curated Info