Ser347
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.4
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser347  -  NRF2 (human)

Site Information
NDSDsGIsLNTsPSV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 18258501

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )

Upstream Regulation
Putative in vivo kinases:
GSK3B (human) ( 2 )
Kinases, in vitro:
GSK3B (human) ( 2 )
Treatments:
SB216763 ( 2 )

Downstream Regulation
Effects of modification on NRF2:
molecular association, regulation ( 2 ) , protein degradation ( 1 , 2 ) , ubiquitination ( 2 )
Effects of modification on biological processes:
transcription, inhibited ( 2 )
Induce interaction with:
BTRC (human) ( 2 )

References 

1

Miller WP, et al. (2020) The stress response protein REDD1 promotes diabetes-induced oxidative stress in the retina by Keap1-independent Nrf2 degradation. J Biol Chem 295
32295843   Curated Info

2

Rada P, et al. (2012) Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis. Mol Cell Biol 32, 3486-99
22751928   Curated Info