Tyr1253
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Home > Phosphorylation Site Page: > Tyr1253  -  PLCG1 (mouse)

Site Information
EGsFEARyQQPFEDF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448576

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 2 , 3 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 2 ) , MEF (fibroblast) ( 1 ) , MEF (fibroblast) [IGF1R (mouse)] ( 3 ) , MEF (fibroblast) [PTP1B (mouse), homozygous knockout] ( 1 )

Upstream Regulation
Treatments:
EGF ( 1 ) , fibronectin ( 3 ) , PDGF ( 1 , 2 ) , vanadate ( 2 )

References 

1

Mertins P, et al. (2008) Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics. Mol Cell Proteomics 7, 1763-77
18515860   Curated Info

2

Poulin B, Sekiya F, Rhee SG (2005) Intramolecular interaction between phosphorylated tyrosine-783 and the C-terminal Src homology 2 domain activates phospholipase C-gamma1. Proc Natl Acad Sci U S A 102, 4276-81
15764700   Curated Info

3

Tvorogov D, Wang XJ, Zent R, Carpenter G (2005) Integrin-dependent PLC-gamma1 phosphorylation mediates fibronectin-dependent adhesion. J Cell Sci 118, 601-10
15657076   Curated Info