Ser136
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Home > Phosphorylation Site Page: > Ser136  -  IRAK2 (mouse)

Site Information
VRPVKPRsLLDtGPI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 18262493

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 ) , mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
adipocyte-adipose tissue ( 1 ) , macrophage-bone marrow ( 3 ) , macrophage-bone marrow [DUSP1 (mouse), homozygous knockout] ( 3 ) , macrophage-peritoneum ( 2 )

Upstream Regulation
Treatments:
LPS ( 3 )

Downstream Regulation
Effects of modification on IRAK2:
intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 )
Induce interaction with:
OPA1 (mouse) ( 1 ) , PHB (mouse) ( 1 ) , TIMM50 (mouse) ( 1 )

References 

1

Zhou H, et al. (2020) IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes. Nat Immunol
32778760   Curated Info

2

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

3

Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371
20531401   Curated Info